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Article Publish Status: FREE
Abstract Title:

Effect of apigenin on apoptosis induced by renal ischemia/reperfusion injury in vivo and in vitro.

Abstract Source:

Ren Fail. 2018 Nov ;40(1):498-505. PMID: 30278824

Abstract Author(s):

Xiao Wang, Wei Wang, Jian-Zhong Wang, Cheng Yang, Chao-Zhao Liang

Article Affiliation:

Xiao Wang

Abstract:

OBJECTIVES: This study aims to investigate the effects and molecular mechanisms of apigenin (ApI) on renal ischemia/reperfusion (I/R) injury in vivo and in vitro.

METHODS: In vivo, the left renal artery was clamped for 45 min and the right kidney was removed to study renal I/R injury on Sprague-Dawley (SD) rats. ApI was injected at 60 min before renal ischemia. In vitro, renal tubular epithelial cells (HK-2) were pretreated with or without ApI (20 uM) for 60 min and then treated with hypoxia/reoxygenation (H/R). Renal function, histology, cells apoptosis, and cell viability were tested. Furthermore, the potential molecular mechanisms were assessed.

RESULTS: ApI pretreatment could significantly alleviated the renal function and the pathological damage as well as cells apoptosis after I/R injury. Meanwhile, ApI treatment protects H/R induced HK-2 cell apoptosis in vitro. The results of Western blot showed that ApI significantly increased the expressions of B-cell lymphoma 2 (Bcl-2) and phosphor-AKt (p-AKt), Phosphoinositide 3-kinase (PI3K), while down-regulated the expressions of Caspase3 and Bax induced by H/R injury.

CONCLUSIONS: ApI pretreatment can protect renal function against I/R injury and prevent renal tubular cells from apoptosis in vivo and in vitro which might through PI3K/Akt mediated mitochondria-dependent apoptosis signaling pathway.

Study Type : Animal Study, In Vitro Study

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