Abstract Title:

Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation.

Abstract Source:

Mol Nutr Food Res. 2015 Apr ;59(4):763-72. Epub 2015 Feb 23. PMID: 25641956

Abstract Author(s):

Daniel Arango, Mayra Diosa-Toro, Laura S Rojas-Hernandez, Jessica L Cooperstone, Steven J Schwartz, Xiaokui Mo, Jinmai Jiang, Thomas D Schmittgen, Andrea I Doseff

Article Affiliation:

Daniel Arango


SCOPE: High incidence of inflammatory diseases afflicts the increasing aging-population infringing a great health burden. Dietary flavonoids, including the flavone apigenin, are emerging as important anti-inflammatory nutraceuticals due to their health benefits, lack of adverse effects and reduced costs. MicroRNAs (miRs) play a central role in inflammation by regulating gene expression, yet how dietary ingredients affect miRs is poorly understood. The aim of this study was to identify miRs involved in the anti-inflammatory activity of apigenin and apigenin-rich diets and determine their immune regulatory mechanisms in macrophages and in vivo.

METHODS AND RESULTS: A high-throughput quantitative reverse transcriptase PCR screen of 312 miRs in macrophages revealed that apigenin reduced LPS-induced miR-155 expression. Analyses of miR-155 precursor and primary transcript indicated that apigenin regulated miR-155 transcriptionally. Apigenin-reduced expression of miR-155 led to the increase of anti-inflammatory regulators forkhead box O3a and smooth-muscle-actin and MAD-related protein 2 in LPS-treated macrophages. In vivo, apigenin or a celery-based apigenin-rich diet reduced LPS-induced expression of miR-155 and decreased tumor necrosis factorα in lungs from LPS-treated mice.

CONCLUSION: These results demonstrate that apigenin and apigenin-rich diets exert effective anti-inflammatory activity in vivo by reducing LPS-induced expression of miR-155, thereby restoring immune balance.

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Sayer Ji
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