Apoptosis and antitumor effects betweenβ-elemene and astragaloside and drug mechanism analysis.
Pak J Pharm Sci. 2018 Sep ;31(5(Special)):2271-2276. PMID: 30463823
β-elemene is an effective anticancer drug extracted from Rhizoma curcumae. It is a non cytotoxic antineoplastic agent, which can obviously inhibit the proliferation of tumor cells. In this paper, we observed the proliferation inhibition and apoptosis of β-elemene and Astragaloside on human hepatoma cell HepG2 and mouse hepatoma H22 cells, and provide a reference for further proof that β-elemene and astragaloside can induce tumor cell apoptosis. The results showed that after 24 h, group astragaloside, β-elemene group and combined treatment group had inhibitory effect on the proliferation ofHePG2 cells, in which the combined treatment group had the best effect and the inhibition rate reached 66.71%. The apoptosis rates of Hep G2 cells in the drug treatment group were 0.9%, 22.4% and 45.8%, respectively, and there was statistical significance in each drug group compared with the control group (P<0.05). It can be seen that Astragalus membranaceus andβ-elemene have obvious inhibitory effects on the growth of liver cancer cells and their combination has synergistic effect.