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Article Publish Status: FREE
Abstract Title:

Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells.

Abstract Source:

Biol Pharm Bull. 2009 Oct ;32(10):1760-4. PMID: 19801840

Abstract Author(s):

Jae-Hee Hyun, Sang-Cheol Kim, Jung-Il Kang, Min-Kyoung Kim, Hye-Jin Boo, Jung-Mi Kwon, Young-Sang Koh, Jin-Won Hyun, Deok-Bae Park, Eun-Sook Yoo, Hee-Kyoung Kang

Article Affiliation:

School of Medicine, Institute of Medical Sciences, Jeju National University, South Kore.

Abstract:

The antitumor activity of fucoidan from Fucus vesiculosus was investigated in human colon carcinoma cells. The crude fucoidan, a polysaccharide composed predominantly of sulfated fucose, markedly inhibited the growth of HCT-15 cells (human colon carcinoma cells). After HCT-15 cells were treated with fucoidan, several apoptotic events such as DNA fragmentation, chromatin condensation and increase of the population of sub-G1 hypodiploid cells were observed. In the mechanism of fucoidan-induced apoptosis, we examined changes in Bcl-2 and Bax protein expression levels and activation of caspases. Fucoidan decreased Bcl-2 expression, whereas the expression of Bax was increased in a time-dependent manner compared to the control. In addition, the active forms of caspase-9 and caspase-3 were increased, and the cleavage of poly(ADP-ribose) polymerase (PARP), a vital substrate of effector caspase, was observed. Furthermore, the induction of apoptosis was also accompanied by a strong activation of extracellular signal-regulated kinase (ERK) and p38 kinase and an inactivation of phosphatidylinositol 3-kinase (PI3K)/Akt in a time-dependent manner. These findings provide evidence demonstrating that the pro-apoptotic effect of fucoidan is mediated through the activation of ERK, p38 and the blocking of the PI3K/Akt signal pathway in HCT-15 cells. These data support the hypothesis that fucoidan may have potential in colon cancer treatment.

Study Type : In Vitro Study

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Sayer Ji
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