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Abstract Title:

Apple pectin-derived oligosaccharides produce carbon dioxide radical anion in Fenton reaction and prevent growth of Escherichia coli and Staphylococcus aureus.

Abstract Source:

Food Res Int. 2017 Oct ;100(Pt 2):132-136. Epub 2017 Aug 19. PMID: 28888433

Abstract Author(s):

Jelena Martinov, Miodrag Krstić, Snežana Spasić, Srdjan Miletić, Jovana Stefanović-Kojić, Aleksandra Nikolić-Kokić, Duško Blagojević, Ivan Spasojević, Mihajlo B Spasić

Article Affiliation:

Jelena Martinov

Abstract:

Pectin is the main soluble fiber in apples or citruses. It may be fermented by gut microbiota to metabolites showing local intestinal and systemic effects. A wide range of beneficial effects of dietary pectin includes impacts on the redox milieu and microbiota profile. We prepared pectin-derived oligosaccharides (apple (APDO) and citrus) and polygalacturonic acid-derived oligosaccharides, using alkaline hydrolysis by hydrogen peroxide, and analyzed them by Fourier Transform Infrared spectrometry. Furthermore, we analyzed the effects of pectin-derived oligosaccharides on hydroxyl radical (HO)-generating Fenton reaction using electron paramagnetic resonance spin-trapping spectroscopy, and the effects on the growth of Escherichia coli and Staphylococcus aureus in the presence of dietary-relevant HO-generating system (iron+ascorbate). The oligosaccharides react with HO radical to produce carbon dioxide radical anion (CO). A comparative analysis showed that APDO has the most prominent bacteriostatic effect. This might be at least partially related to the higher capacity of APDO to produce CO, which specifically targets proteins and appears to have a longer lifetime and larger diffusion radius in biological systems compared to HO.

Study Type : In Vitro Study

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