n/a
Article Publish Status: FREE
Abstract Title:

Aqueous extract offruit pulp exhibits antihyperglycaemic activity.

Abstract Source:

Avicenna J Phytomed. 2020 Sep-Oct;10(5):440-447. PMID: 32995322

Abstract Author(s):

Rajesh Nivesh Krishna, Roy Anitha, Devaraj Ezhilarasan

Article Affiliation:

Rajesh Nivesh Krishna

Abstract:

Objective: Linn. () is a well-known plant used in traditional medicine. The plant is popular for its antidiabetic activity. However, effect so f its aqueous fruit pulp extract on carbohydrate hydrolyzing enzymes and its glucose uptake potential were not explored.

Materials and Methods: The antidiabetic activity was assessed byα-amylase and α-glucosidase inhibitory assays after preliminary phytochemical analysis. MTT assay was carried out to find cytotoxicity. Glucose uptake activity of the extract was carried out using L6 myotubes.

Results: The results showed a strongα-amylase inhibitory activity for the fruit pulp extract ofcompared to standard acarbose; the ICof the fruit pulp extract ofand acarbose was 34.19µg/ml 34.83µM. The extract also showed moderate α-glucosidase inhibitory activity. ICof the fruit pulp extract ofand acarbose were 56.91µg/ml and 45.69µM respectively. The cytotoxicity assay showed ICof>300µg/ml and ≥1000µM for the fruit pulp extract ofand metformin. The extract showed 63.99±0.08% glucose uptake in L6 myotubes whereas metformin and insulin at 10µg/ml and 10µM exhibited an uptake of 76.99±0.3% and 84.48±0.45% glucose, respectively.

Conclusion: The study revealed that the fruit pulp extract ofLinn does not show any cytotoxic effect and has very goodα-amylase and good α-glucosidase inhibitory activities. The glucose uptake potential proves its postprandial hypoglycemic effect. Hence, it may be considered an antidiabetic agent for control of postprandial hyperglycemia.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.