Article Publish Status: FREE
Abstract Title:

The Ameliorating Effect of Myrrh on Scopolamine-Induced Memory Impairments in Mice.

Abstract Source:

Evid Based Complement Alternat Med. 2015;2015:925432. Epub 2015 Nov 9. PMID: 26635888

Abstract Author(s):

Samrat Baral, Du-Hyong Cho, Ramesh Pariyar, Chi-Su Yoon, Bo-Yoon Chang, Dae-Sung Kim, Hyoung-Kwon Cho, Sung Yeon Kim, Hyuncheol Oh, Youn-Chul Kim, Jaehyo Kim, Jungwon Seo

Article Affiliation:

Samrat Baral

Abstract:

Myrrh has been used since ancient times for the treatment of various diseases such as inflammatory diseases, gynecological diseases, and hemiplegia. In the present study, we investigated the effects of aqueous extracts of myrrh resin (AEM) on scopolamine-induced memory impairments in mice. AEM was estimated with (2E,5E)-6-hydroxy-2,6-dimethylhepta-2,4-dienal as a representative constituent by HPLC. The oral administration of AEM for 7 days significantly reversed scopolamine-induced reduction of spontaneous alternation in the Y-maze test. In the passive avoidance task, AEM also restored the decreased latency time of the retention trial by scopolamine treatment. In addition, Western blot analysis and Immunohistochemistry revealed that AEM reversed scopolamine-decreased phosphorylation of Akt and extracellular signal-regulated kinase (ERK). Our study demonstrates for the first time that AEM ameliorates the scopolamine-induced memory impairments in mice and increases the phosphorylation of Akt and ERK in the hippocampus of mice brain. These results suggest that AEM has the therapeutic potential in memory impairments.

Study Type : Animal Study

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