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Abstract Title:

Effect of Hypericum perforatum Aqueous Extracts on Serum Lipids, Aminotransferases, and Lipid Peroxidation in Hyperlipidemic Rats.

Abstract Source:

Res Cardiovasc Med. 2016 May ;5(2):e31326. Epub 2016 Mar 5. PMID: 26949689

Abstract Author(s):

Mohammad Hassan Ghosian Moghaddam, Mehrdad Roghani, Maryam Maleki

Article Affiliation:

Mohammad Hassan Ghosian Moghaddam


BACKGROUND: Patients with high levels of total cholesterol (TCH), low-density lipoprotein cholesterol (LDL-CH), and triglyceride (TG) are at increased risk of coronary heart disease. Studies have shown that flavonoids and antioxidant compounds have beneficial effects on hyperlipidemia.

OBJECTIVES: The aim of the present study was to evaluate the effects of extract of Hypericum perforatum (EHP) on the serum lipid profile (TCH, TG, and LDL-CH), aminotransferase, alkaline phosphatase, and lipid peroxidation in hyperlipidemic rats.

MATERIALS AND METHODS: Thirty-two male rats weighting 200± 10 g were randomly divided into four experimental groups: 1) control, 2) control + EHP, 3) hyperlipidemia, and 4) hyperlipidemia + EHP. The rats in the hyperlipidemic groups were fed a high-fat diet for 60 days, and EHP (300 mg/kg) was injected intraperitoneally for 2 weeks in the rats in the second and fourth groups. At the end of the experimental period, blood samples from each group were analyzed.

RESULTS: There was a significant reduction in LDL-CH in the control + EHP group and the hyperlipidemia + EHP group (P<0.05). TCH was significantly reduced in the control + EHP group (P<0.05). There were no significant changes in the levels of TG and HDL-CH. Malondialdehyde, aspartate aminotransferase, and alanine aminotransferase were significantly reduced in the hyperlipidemia + EHP group (P<0.05), with no significant change in alkaline phosphatase.

CONCLUSIONS: EHP was able to both reduce LDL-CH and to significantly decrease markers of oxidative stress and lipid peroxidation induced by hyperlipidemia. Therefore, this herb, as a new pharmacological component, could be used to reduce certain blood lipids, lipid peroxidation, and aminotransferase markers.

Study Type : Animal Study

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