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Article Publish Status: FREE
Abstract Title:

Extract Suppresses Inflammation and Inhibits Melanoma Progression.

Abstract Source:

Medicines (Basel). 2019 Jul 29 ;6(3). Epub 2019 Jul 29. PMID: 31362372

Abstract Author(s):

Bruno A C Nascimento, Luiz G Gardinassi, Inaê M G Silveira, Marília G Gallucci, Mariana A Tomé, Júlia Fernanda D Oliveira, Mirella R A Moreira, Alyne F G Meirelles, Lúcia H Faccioli, Cristiane Tefé-Silva, Karina F Zoccal

Article Affiliation:

Bruno A C Nascimento

Abstract:

Arctium lappa has been used as popular medicinal herb and health supplement in Chinese societies. Bioactive components fromhave attracted the attention of researchers due to their promising therapeutic effects. In this study, we investigated the effects ofhydroalcoholic extract (Alhe) during different models of inflammation, in vivo.The anti-inflammatory activity was evaluated through the air pouch model. For this, mice received an inflammatory stimulus with lipopolysaccharide (LPS) and were later injected with Alhe. To assess anti-tumoral activity, the animals were inoculated with B16F10 cells and injected with Alhe every 5 days, along the course of 30 days. Controls were submitted to the same conditions and injected with the vehicle. Peritoneal or air pouch fluids were collected to evaluate leukocyte counting or cellular activation via quantification of cytokines and nitric oxide.Alhe injection reduced the neutrophil influx and production of inflammatory mediators in inflammatory foci after LPS or tumor challenges. Furthermore, Alhe injection reduced tumor growth and enhanced mice survival.Collectively, these data suggest that Alhe regulates immune cell migration and activation, which correlates with favorable outcome in mouse models of acute inflammation and melanoma progression.

Study Type : Animal Study

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