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Abstract Title:

Phytochemical Analysis and Antidiabetic Potential of Armoracia Rusticana: Pharmacological and Computational Approach.

Abstract Source:

Comb Chem High Throughput Screen. 2020 May 26. Epub 2020 May 26. PMID: 32452324

Abstract Author(s):

Anam Javaid, Usman Ali Ashfaq, Zeeshan Zafar, Arina Akmal, Saman Taj, Hina Khalid

Article Affiliation:

Anam Javaid

Abstract:

: Aims&Objective: Armoracia Rusticana has high medicinal values and is an excellent source of phytochemicals. This study was aimed to evaluate the antidiabetic potential of bioactive compounds from Armoracia Rusticana.

METHODS: The antidiabetic analysis revealed Armoracia Rusticana was highly active againstα-glucosidase with IC50 values of 5.6 µg/ml. Furthermore, molecular docking was used to identify the active constituents against α-glucosidase, while using acarbose as a controlled drug.

RESULTS: Upon phytochemical screening, it was found that six out of ten phytochemicals were successfully docked in the respective binding sites. The lead phytochemical was Quercetin 3-O-beta-D-xylopyranoside which displayed a more binding score as compared to acarbose. They were subjected to analyze for drug-like properties which further strengthen its validation.

CONCLUSION: It was, therefore, concluded that Armoracia Rusticana might potentially be used in the amelioration of type 2 diabetes. Potential molecules identified from this study could be considered as a lead drug to cure diabetes mellitus.

Study Type : In Vitro Study

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