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Abstract Title:

Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities.

Abstract Source:

Fitoterapia. 2019 Feb 11 ;134:58-64. Epub 2019 Feb 11. PMID: 30763720

Abstract Author(s):

Shuang-Yang Lu, Xing-Rong Peng, Jin-Run Dong, Hui Yan, Qing-Hua Kong, Qiang-Qiang Shi, Da-Shan Li, Lin Zhou, Zhong-Rong Li, Ming-Hua Qiu

Article Affiliation:

Shuang-Yang Lu

Abstract:

Five new aromatic compounds, designed as lucidumins A-D (1-4) and lucidimine E (9), along with seven known aromatic compounds (5-8, 10-12) were isolated from Ganoderma lucidum. Their structures were determined by spectroscopic method. Bioactive evaluation showed that compounds 2-4 and 6-10 displayed remarkable neuroprotective activities against corticosterone-induced PC12 cell damage, with the cell viability ranging from 69.99% to 126.00%; and compounds 1-4, 9 and 10 exhibited significant anti-inflammatory activities against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, with ICvalues ranging from 4.68 to 15.49 μM. In particular, compound 10 showed remarkable neuroprotection with ECvalue of 2.49 ± 0.12 μM, and potent anti-inflammation with ICvalue of 4.68 ± 0.09 μM.

Study Type : In Vitro Study

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