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Abstract Title:

Dietary Prevention of Colitis by Aronia Berry is Mediated Through Increased Th17 and Treg.

Abstract Source:

Mol Nutr Food Res. 2019 03 ;63(5):e1800985. Epub 2018 Dec 13. PMID: 30521111

Abstract Author(s):

Ruisong Pei, Derek A Martin, Jonathan C Valdez, Jiyuan Liu, Robert L Kerby, Federico E Rey, Joan A Smyth, Zhenhua Liu, Bradley W Bolling

Article Affiliation:

Ruisong Pei

Abstract:

SCOPE: Increased fruit consumption is associated with reduced risk of colitis. It has been investigated whether the anti-colitic effects of the polyphenol-rich aronia berry (Aronia mitschurinii 'Viking') are mediated through Th17 and Treg.

METHODS AND RESULTS: Colitis is induced in recombinase activating gene-1 deficient mice injected with syngeneic CD4CD62Lnaïve T cells. Mice consume either 4.5% w/w aronia-berry-supplemented or a control diet concurrent with T cell transfer. The extent of colitis and immunocyte populations are evaluated at weeks 3 to 7 after transfer. Aronia consumption prevents colitic wasting and reduces colon weight/length ratios relative to the control diet at weeks 5 and 7. Compared to the control diet, aronia feeding increases Treg in mesenteric lymph node at all colitis stages. Treg and regulatory Th17 subpopulations (IL-17AIL-10and IL-17AIL-22) are increased in lamina propria and spleen at week 5 in aronia-fed mice. Aronia feeding also decreases total CD4cells but increases colonic Tregs. The ability of aronia to modulate colonic cytokines is associated with functional T cell IL-10 and increased diversity of microbiota.

CONCLUSIONS: Aronia berry consumption inhibits adoptive transfer colitis by increasing Treg and regulatory Th17 cells. Dietary modulation of T cells is dynamic and precedes colitic wasting.

Study Type : Animal Study

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