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Abstract Title:

Lmodulates the immune system in a multiple sclerosis mouse model.

Abstract Source:

Nutr Neurosci. 2019 Oct 31:1-7. Epub 2019 Oct 31. PMID: 31665978

Abstract Author(s):

Hamidreza Safari, Gholamreza Anani Sarab, Mohsen Naseri

Article Affiliation:

Hamidreza Safari

Abstract:

: Multiple sclerosis along with its animal model, experimental autoimmune encephalomyelitis (EAE), are chronic inflammatory and degenerative diseases of the central nervous system (CNS). Due to the unknown cause of the disease, the most common treatments of MS are targeted for the reduction of inflammation and the repairment of CNS tissue damage, especially myelin restoration. Due to the immune protective nature of herbs, it may be useful to evaluate the impact of herbs in the diet regimen of MS patients along with their immune-mediated effects. The purpose of this study was to investigate the effect of an aqueous extract of(Tarragon) on the treatment of EAE in C57BL/6 mice.In this experimental study, mice were divided into the following control, untreated EAE, andtreated EAE groups. EAE was induced by myelin oligodendrocyte glycoprotein (MOG35-55) in female C57BL/6 mice. The symptoms of the disease and the weight of the mice were recorded daily. On day 33 after EAE induction, the mice were sacrificed and the specimens were collected. Cell proliferation and cytokine release (TGF-β, IL-17 and IL-23) from mice cultured spleen cells was measured by 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and ELISA respectively.Administration of the extract ofmitigated EAE symptoms (< 0.05). Furthermore, there was a reduction in the levels of inflammatory cytokines including IL-17 (= 0.009) and IL-23 (= 0.012) and confirmed increased serum antioxidant levels intreated EAE mice (= 0.008).These observations indicate thatextracts could reduce inflammatory cytokines and attenuate certain signs of EAE, suggesting the potential of a useful adjuvant therapy for MS.

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