n/a
Abstract Title:

Ascorbic acid and CoQ10 ameliorate the reproductive ability of SOD1-deficient female mice.

Abstract Source:

Biol Reprod. 2019 Aug 2. Epub 2019 Aug 2. PMID: 31373359

Abstract Author(s):

Naoki Ishii, Takujiro Homma, Jaeyong Lee, Hikaru Mitsuhashi, Ken-Ichi Yamada, Naoko Kimura, Yorihiro Yamamoto, Junichi Fujii

Article Affiliation:

Naoki Ishii

Abstract:

Superoxide dismutase 1 (SOD1) suppresses oxidative stress within cells by decreasing the levels of superoxide anions. A dysfunction of the ovary and/or an aberrant production of sex hormones are suspected causes for infertility in SOD1-knockout (KO) mice. We report on attempts to rescue the infertility in female KO mice by providing two antioxidants, ascorbic acid (AsA) and/or coenzyme Q10 (CoQ10), as supplements in the drinking water of the KO mice after weaning and on an investigation of their reproductive ability. On the first parturition, 80% of the untreated KO mice produced smaller litter sizes compared to wild-type mice (average 2.8 vs 7.3 pups/mouse), and supplementing with these antioxidants failed to improve these litter sizes. However, in the second parturition of the KO mice, the parturition rate was increased from 18% to 44-75% as the result of the administration of antioxidants. While plasma levels of progesterone at 7.5 days of pregnancy were essentially the same between the WT and KO mice and were not changed by supplementation of these antioxidants, sizes of corpus luteum cells, which were smaller in the KO mouse ovaries after the first parturition, were significantly ameliorated in the KO mouse with the administration of the antioxidants. Moreover, the impaired vasculogenesis in uterus/placenta was also improved by AsA supplementation. We thus conclude that AsA and/or CoQ10 are involved in maintaining ovarian and uterus/placenta homeostasis against insults that are augmented during pregnancy and that their use might have positive effects in terms of improving female fertility.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.