n/a
Abstract Title:

Anti-Cancer Effects of Asiatic Acid, A Triterpene From Centilla Asiatica L: A Literature Review.

Abstract Source:

Anticancer Agents Med Chem. 2019 Dec 10. Epub 2019 Dec 10. PMID: 31823705

Abstract Author(s):

Muhammad T Islam, Eunus S Ali, Shaikh J Uddin, Ishaq N Khan, Manik C Shill, João M de Castro E Sousa, Marcus V O Barros de Alencar, Ana A C Melo-Cavalcante, Mohammad S Mubarak

Article Affiliation:

Muhammad T Islam

Abstract:

BACKGROUND: Centilla asiatica L is a medicinal herb that has been widely used in folk medicine to treat various diseases. Asiatic Acid (AA), a triterpene and a known component of this herb, has been shown to display important biological activities, including anti-inflammatory, antibacterial, antidiabetic and anti-hyperlipidemic, neuroprotective, anxiolytic and antidepressant, hepatoprotective, pancrease protective, and cardio-protective.

OBJECTIVE: This review focuses on AA's anti-cancer effects on the basis of published literature found in a number of databases such as PubMed and Science. Emphasis has been given to the mechanisms of action of its anti-cancer effect.

METHODS: A literature survey was conducted through May 2019 using known databases such as PubMed and Science Direct using the keyword 'Asiatic acid', pairing with 'cancer', 'tumor', 'anti-cancer effect', 'cytotoxic effect', 'anti-tumor activity', 'cell line', 'animal cancer', and 'human cancer'.

RESULTS: Findings suggest that AA exerts anti-cancer effects in several test systems through various pathways, including oxidative/antioxidant, anti-inflammatory, cytotoxicity, apoptotic cell death, necrosis, anti-angiogenesis, inhibition of proliferation and cell migration, and chemoprevention.

CONCLUSIONS: AA may be an effective plant-based cancer chemotherapeutic agent and a promising lead for the development of potent anticancer drugs.

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.