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Abstract Title:

Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis.

Abstract Source:

Eur J Pharmacol. 2012 Mar 15 ;679(1-3):51-9. Epub 2012 Jan 24. PMID: 22296759

Abstract Author(s):

Xiangnan Zhang, Jiaying Wu, Yuan Dou, Binbin Xia, Weibo Rong, Gerald Rimbach, Yijia Lou

Article Affiliation:

Xiangnan Zhang

Abstract:

Ceramides derived from sphingosine contribute to the apoptotic processes of neuronal cells in neurodegenerative disorders including Alzheimer's disease. This study investigates the potential neuroprotective effects of Asiatic acid, a triterpenoid derived from Centella asiatica, against C(2)-ceramides-induced cell death in primary cultured rat cortical neuronal cells. In primary neurons, Asiatic acid (0.01 to 1.0μmol/l) reduced C(2)-ceramide-induced cell death and mitochondria membrane potential loss in a concentration-dependent manner. Furthermore, Asiatic acid decreased cellular production of reactive oxygen species following C(2)-ceramide treatment. At a maximal concentration of 1.0 μmol/l, Asiatic acid partly counteracted the pro-apoptotic effects of the C(2)-ceramide by reducing the cytosolic release of HtrA2/Omi, the upregulation of Bax and caspase 3, as well as the dephosphorlyation of ERK1/2. Taken together, these data suggest that Asiatic acid protects neurons from C(2)-ceramide-induced cell death by antagonizing mitochondria-dependent apoptosis.

Study Type : In Vitro Study

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Sayer Ji
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