Abstract Title:

The association of e-cigarette use with exposure to nickel and chromium: A preliminary study of non-invasive biomarkers.

Abstract Source:

Environ Res. 2017 11 ;159:313-320. Epub 2017 Aug 21. PMID: 28837903

Abstract Author(s):

Angela Aherrera, Pablo Olmedo, Maria Grau-Perez, Stefan Tanda, Walter Goessler, Stephanie Jarmul, Rui Chen, Joanna E Cohen, Ana M Rule, Ana Navas-Acien

Article Affiliation:

Angela Aherrera


BACKGROUND: Nickel (Ni) and chromium (Cr) are components of e-cigarette heating coils. Whether e-cigarettes increase metal internal dose, however, is unknown. We assessed the association of e-cigarette use patterns and of e-liquid and aerosol metal concentrations with Ni and Cr biomarker levels in e-cigarette users from Maryland.

METHODS: We recruited 64 e-cigarette users from December 2015 to March 2016. We collected urine, saliva, and exhaled breath condensate (EBC), data on e-cigarette use, and samples from their e-cigarette device (dispenser e-liquid, aerosol, and tank e-liquid).

RESULTS: Median Ni and Cr levels were 0.73 and 0.39μg/g creatinine in urine, 2.25 and 1.53μg/L in saliva, and 1.25 and 0.29μg/L in EBC. In adjusted models, tertiles 2 and 3 of aerosol Ni concentrations were associated with 16% and 72% higher urine Ni and 202% and 321% higher saliva Ni compared to the lowest tertile. Tertile 3 of aerosol Cr levelswere associated with 193% higher saliva Cr. An earlier time to first vape in the morning and more frequent coil change were associated with higher urine Ni. Tertile 2 of e-liquid consumption per week and voltage were associated with higher saliva Ni levels than tertile 1.

CONCLUSION: Positive associations of Ni and Cr aerosol concentrations with corresponding Ni and Cr biomarker levels indicate e-cigarette emissions increase metal internal dose. Increased e-cigarette use and consumption were also associated with higher Ni biomarker levels. Metal level standards are needed to prevent involuntary metal exposure among e-cigarette users.

Study Type : Human Study
Additional Links
Additional Keywords : Risk Factors : CK(3057) : AC(392)

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Sayer Ji
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