Associations of particulate matter sizes and chemical constituents with blood lipids. - GreenMedInfo Summary
Associations of Particulate Matter Sizes and Chemical Constituents with Blood Lipids: A Panel Study in Guangzhou, China.
Environ Sci Technol. 2021 Mar 25. Epub 2021 Mar 25. PMID: 33764049
Existing evidence is scarce concerning the various effects of different PM sizes and chemical constituents on blood lipids. A panel study that involved 88 healthy college students with five repeated measurements (440 blood samples in total) was performed. We measured mass concentrations of particulate matter with diameters≤ 2.5 μm (PM),≤1.0 μm (PM), and≤0.5 μm (PM) as well as number concentrations of particulate matter with diameters≤ 0.2 μm (PN) and≤0.1 μm (PN). We applied linear mixed-effect models to assess the associations between short-term exposure to different PM size fractions and PMconstituents and seven lipid metrics. We found significant associations of greater concentrations of PM in different size fractions within 5 days before blood collection with lower high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A (ApoA1) levels, higher apolipoprotein B (ApoB) levels, and lower ApoA1/ApoB ratios. Among the PMconstituents, we observed that higher concentrations of tin and lead were significantly associated with decreased HDL-C levels, and higher concentrations of nickel were associated with higher HDL-C levels. Our results suggest that short-term exposure to PM in different sizes was deleteriously associated with blood lipids. Some constituents, especially metals, might be the major contributors to the detrimental effects.