Astaxanthin Inhibits-induced Inflammatory and Oncogenic Responses in Gastric Mucosal Tissues of Mice.
J Cancer Prev. 2020 Dec 30 ;25(4):244-251. PMID: 33409257
is recognized as a risk factor for gastric carcinogenesis. The chronic exposure of gastric epithelium toinduces a prolonged inflammatory state that may progress to gastric cancer. Astaxanthin, a pinkish antioxidant carotenoid, abundant in marine organisms, is known for its protective effect against inflammation and multiple types of cancer. The purpose of this study was to examine the effect of astaxanthin on-induced oxidative injury, inflammation, and oncogene expression in gastric mucosal tissues of the infected mice. Mice were inoculated using oral gavage withsuspension (10colony forming unit of/0.1 mL) for three days, after which they were fed astaxanthin-supplemented diet (5 mg/kg body weight/day for seven weeks). The effects of astaxanthin on-induced increase in lipid peroxide (LPO) production, myeloperoxidase (MPO) activity, expression of the inflammatory cytokine IFN-and oncogenes (c-myc and cyclin D1), and the accompanying histologic changes in gastric mucosal tissues were evaluated.infection increased the level of LPO, MPO activity, and the expression of IFN-, c-myc, and cyclin D1 in gastric mucosal tissues of mice.infection induced neutrophil infiltration and hyperplasia of gastric mucosa. Astaxanthin supplementation attenuated these effects. In conclusion, consumption of astaxanthin-rich foods may prevent-associated oxidative damage and inflammatory and oncogenic responses in gastric mucosal tissues.