Astaxanthin prevents in vitro auto-oxidative injury in human lymphocytes. - GreenMedInfo Summary
Astaxanthin prevents in vitro auto-oxidative injury in human lymphocytes.
Cell Biol Toxicol. 2010 Oct;26(5):457-67. Epub 2010 Mar 14. PMID: 20229275
Cellular Physiology Laboratory, Postgraduate Program-Health Science, CBS, Cruzeiro do Sul University, Tatuapé, São Paulo, Brazil.
Upon mitogen sensitization, lymphocytes undergo proliferation by oxyradical-based mechanisms. Through continuous resting-restimulation cycles, lymphocytes accumulate auto-induced oxidative lesions which lead to cell dysfunction and limit their viability. Astaxanthin (ASTA) is a nutritional carotenoid that shows notable antioxidant properties. This study aims to evaluate whether the in vitro ASTA treatment can limit oxyradical production and auto-oxidative injury in human lymphocytes. Activated lymphocytes treated with 5 microM ASTA showed immediate lower rates of O(2)(*-) /H(2)O(2) production whilst NO* and intracellular Ca(2+) levels were concomitantly enhanced (