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Article Publish Status: FREE
Abstract Title:

Asthmatic Patients with Vitamin D Deficiency have Decreased Exacerbations after Vitamin Replacement.

Abstract Source:

Nutrients. 2017 Nov 11 ;9(11). Epub 2017 Nov 11. PMID: 29137124

Abstract Author(s):

Paolo Solidoro, Michela Bellocchia, Ilaria Aredano, Alessio Mattei, Emanuele Pivetta, Filippo Patrucco, Monica Boita, Francesca de Blasio, Luisa Brussino, Giovanni Rolla, Caterina Bucca

Article Affiliation:

Paolo Solidoro

Abstract:

BACKGROUND: Intervention studies with vitamin D in asthma are inconclusive for several reasons, such as inadequate dosing or duration of supplementation or uncontrolled baseline vitamin D status. Our aim was to evaluate the benefit of long term vitamin D add-on in asthmatic patients with actual vitamin D deficiency, that is a serum 25-hydroxy vitamin D (25-OHD ) below 20 ng/mL.

METHODS: Serum 25-OHD, asthma exacerbations, spirometry and inhaled corticosteroids (CS) dose were evaluated in a cohort of 119 asthmatic patients. Patients with deficiency were evaluated again after one year vitamin supplementation.

RESULTS: 25-OHD was low in 111 patients and was negatively related to exacerbations (p<0.001), inhaled CS dose (p = 0.008) and asthma severity (p = 0.001). Deficiency was found in 90 patients, 55 of whom took the supplement regularly for one year, while 24 discontinued the study and 11 were not adherent. Patients with vitamin D deficiency after 12 months supplementation showed significant decrease of exacerbations (from 2.6± 1.2 to 1.6 ± 1.1, p<0.001), circulating eosinophils (from 395± 330 to 272 ± 212 10⁶/L, p<0.001), and need of oral CS courses (from 35 to 20, p = 0.007) and improvement of airway obstruction.

CONCLUSIONS: Asthma exacerbations are favored by vitamin D deficiency and decrease after long-term vitamin D replacement. Patients who are vitamin D deficient benefit from vitamin D supplementation.

Study Type : Human Study

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