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Article Publish Status: FREE
Abstract Title:

Astragaloside IV Exerts Cardioprotection in Animal Models of Viral Myocarditis: A Preclinical Systematic Review and Meta-Analysis.

Abstract Source:

Front Pharmacol. 2019 ;10:1388. Epub 2019 Nov 28. PMID: 31849654

Abstract Author(s):

Zhuang Zhuang, Zi-Hao Wang, Li-Hui Deng, Qun Zheng, Guo-Qing Zheng, Yan Wang

Article Affiliation:

Zhuang Zhuang

Abstract:

Astragaloside IV (AS-IV), the essential active component of astragalus, possesses diverse biological activities that have beneficial effects against cardiovascular disease. Here, we conducted a preclinical systematic review of 15 studies including 577 animals to establish the efficacy and potential mechanisms of AS-IV for animal models of viral myocarditis (VM). Six databases were searched from inception to October 2018. Application of the Cochrane Collaboration's tool 10-item checklist and Rev-Man 5.3 software to analyze risk of bias of studies and data on outcome measures revealed study quality scores ranging from 2 to 5. Compared with the control group, AS-IV induced a marked decrease in mortality (P<0.05), inflammation of myocardium and pathological score (P<0.05) and cardiac enzymes expression (P<0.05), and improved the function of the heart (P<0.05). The potential mechanisms of AS-IV action were determined as anti-remodeling of myocardium (n = 1), anti-virus (n = 2), antioxidant (n = 2), anti-inflammatory (n = 6), anti-apoptosis (n = 1) and alleviation of myocardial fibrosis (n = 2). The collective results indicate that AS-IV exerts cardioprotective effects in animals with VMmultiple signaling pathways.

Study Type : Meta Analysis, Review

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