Atractylenolide and its derivates may serve as potential aromatase inhibitors. - GreenMedInfo Summary
Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala Koidz.
Molecules. 2011 Apr 14 ;16(4):3146-51. Epub 2011 Apr 14. PMID: 21494203
Ten compounds were isolated from the dichloromethane extract of Atractylodes macrocephala and their aromatase inhibiting activities were tested using an in vitro fluorescent-based aromatase assay. The results indicated that atractylenolide I, atractylenolide II and atractylenolide III had inhibition ratios of 94.56± 0.70%, 90.93 ± 1.41% and 86.31 ± 8.46%, respectively, at a concentration of 10 μM. We conclude from our results that atractylenolide and its derivates may serve as potential aromatase inhibitors (AIs) and thus merit continued study in the future.