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Article Publish Status: FREE
Abstract Title:

Baicalein decreases uric acid and prevents hyperuricemic nephropathy in mice.

Abstract Source:

Oncotarget. 2017 Jun 20 ;8(25):40305-40317. PMID: 28445133

Abstract Author(s):

Xiaolu Meng, Zhuo Mao, Xin Li, Dandan Zhong, Min Li, Yingli Jia, Jing Wei, Baoxue Yang, Hong Zhou

Article Affiliation:

Xiaolu Meng

Abstract:

Baicalein, a natural flavonoid, is structurally advantageous for binding to xanthine oxidoreductase. In our study, molecular docking analysis and Surface Plasmon Resonance revealed a direct interaction between baicalein and xanthine oxidoreductase. Moreover, 50 mg/kg/d baicalein treatment significantly suppressed the viability of xanthine oxidoreductase in hyperuricemia mouse model. The data showed that baicalein remarkably prevented renal dysfunction, ameliorated kidney fibrosis, alleviated epithelial-mesenchymal transition and oxidative stress in hyperuricemia mice. Thus, we concluded that baicalein executed a kidney-protection action in hyperuricemia and therefore may be used as a therapeutic alternative for hyperuricemic nephropathy.

Study Type : Animal Study

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Sayer Ji
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