Baicalein InhibitsBiofilms and Dental Caries-Related Virulence Phenotypes.
Antibiotics (Basel). 2021 Feb 21 ;10(2). Epub 2021 Feb 21. PMID: 33670013
Dental caries, the most common oral disease, is a major public healthcare burden and affects more than three billion people worldwide. The contemporary understanding of the need for a healthy microbiome and the emergence of antimicrobial resistance has resulted in an urgent need to identify compounds that curb the virulence of pathobionts without microbial killing. Through this study, we have demonstrated for the first time that 5,6,7-trihydroxyflavone (Baicalein) significantly downregulates crucial caries-related virulence phenotypes in. Baicalein significantly inhibited biofilm formation byUA159 (MBIC= 200μM), without significant growth inhibition. Notably, these concentrations of baicalein did not affect the commensal. Strikingly, baicalein significantly reduced cell surface hydrophobicity, autoaggregation and acid production by. Mechanistic studies (qRT-PCR) showed downregulation of various genes regulating biofilm formation, surface attachment, quorum sensing, acid production and competence. Finally, we demonstrate the potential translational value of baicalein by reporting synergistic interaction with fluoride againstbiofilms.