n/a
Abstract Title:

Baicalein represses TGF-β1-induced fibroblast differentiation through the inhibition of miR-21.

Abstract Source:

Toxicol Appl Pharmacol. 2018 11 1 ;358:35-42. Epub 2018 Sep 7. PMID: 30201452

Abstract Author(s):

Xinjian Cui, Xionghua Sun, Fanqing Lu, Xiaogang Jiang

Article Affiliation:

Xinjian Cui

Abstract:

Fibroblast-to-myofibroblast differentiation is a highly important pathological characteristic of pulmonary fibrosis. In this study, we aimed to investigate the effects and mechanisms of baicalein on the differentiation of human lung fibroblasts. Baicalein reduced the levels ofα-smooth muscle actin (α-SMA) mRNA and protein expression in TGF-β1-treated human lung fibroblasts. It also decreased the contents of collagen type I and fibronectin in time- and dose-dependent manners, and retarded TGF-β1-stimulated α-SMA filament formation. Baicalein diminished the expressionof miR-21, and miR-21 mimics partially antagonized the effects of baicalein. Additionally, Baicalein inhibited the miR-21 transcriptor STAT3 activity but not AP-1 activity. Moreover, the expression of Spry 1 protein, a miR-21 known target, was improved by baicalein treatment, but the level of Smurf2 protein, another miR-21 target, was not interfered. Collectively, these results demonstrated that baicalein can attenuate TGF-β1-induced human lung fibroblast differentiation by inhibiting the miR-21 expression.

Study Type : Human In Vitro
Additional Links
Pharmacological Actions : Anti-Fibrotic : CK(1896) : AC(888)

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.