Abstract Title:

In vitro synergism of fluconazole and baicalein against clinical isolates of Candida albicans resistant to fluconazole.

Abstract Source:

Biol Pharm Bull. 2008 Dec;31(12):2234-6. PMID: 19043205

Abstract Author(s):

Shan Huang, Ying Ying Cao, Bao Di Dai, Xuan Rong Sun, Zhen Yu Zhu, Yong Bing Cao, Yan Wang, Ping Hui Gao, Yuan Ying Jiang

Article Affiliation:

School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.

Abstract:

In vitro interaction of fluconazole and baicalein (BE) was investigated against 30 fluconazole-resistant clinical isolates of Candida albicans. Synergistic activities were determined using the checkerboard microdilution assay based on the fractional inhibitory concentration indices. Organisms were also tested against the 2 drugs singly and in combination using time-kill methods. Both fluconazole and BE showed weak antifungal activity when tested alone. However, the combination of fluconazole and BE showed strong antifungal activity against most of the fluconazole-resistant isolates tested. The findings of time-kill curves confirmed the interaction. Yeast cells grown in the presence of BE exhibited a reduced extrusion of Rhodamine 6G, which indicates the inhibition of efflux pumps by BE. This novel synergism of fluconazole and BE that can overcome drug-resistance in yeast may prove useful in combined treatment of fungal infections.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antifungal Agents : CK(403) : AC(237)
Additional Keywords : Drug: Fluconazole : CK(4) : AC(3)

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.