Abstract Title:

Bee venom enhances the differentiation of human regulatory T cells.

Abstract Source:

Allergy. 2015 Oct ;70(10):1340-5. Epub 2015 Jul 30. PMID: 26179427

Abstract Author(s):

I Caramalho, A Melo, E Pedro, M M P Barbosa, R M M Victorino, M C Pereira Santos, A E Sousa

Article Affiliation:

I Caramalho

Abstract:

Venom-specific immunotherapy (VIT) is well recognized by its efficacy, and compelling evidence implicates regulatory T cells (Tregs) in the underlying tolerogenic mechanisms. Additionally, hymenoptera venom has for a long time been claimed to modulate immunity. Here, we investigated the putative role of bee venom (Bv) in human FOXP3-expressing Treg homeostasis and differentiation, irrespective of the donors' allergic status. We found that Bv significantly enhanced the differentiation of FOXP3-expressing cells both from conventional naïve CD4 T cells and mature CD4 thymocytes, a property that may contribute to the VIT's capacity to expand circulating Tregs in allergic individuals. We expect that our data enlightening the Treg-mediated immunomodulatory properties of Bv regardless of TCR specificity, to have application in other allergies, as well as in other clinical settings, such as autoimmunity and transplantation.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Immunomodulatory : CK(4048) : AC(1475)

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