Abstract Title:

Bee venom protects hepatocytes from tumor necrosis factor-alpha and actinomycin D.

Abstract Source:

Leukemia. 2010 May;24(5):986-91. Epub 2010 Mar 25. PMID: 20195821

Abstract Author(s):

Ji-Hyun Park, Kyung-Hyun Kim, Soo-Jung Kim, Woo-Ram Lee, Kwang-Gill Lee, Kwan-Kyu Park

Article Affiliation:

Department of Pathology, Catholic University of Daegu, College of Medicine, Daegu, 705-718, Korea.

Abstract:

Honeybee (Apis mellifera) venom (BV) has a broad array of therapeutic applications in traditional medicine to treat variety of diseases. It is also known that BV possesses anti-inflammatory and anticancer effect and that it can inhibit proliferation and induces apoptosis in cancer cells, but there is no evidence of information regarding anti-apoptosis of BV on hepatocytes. In the present study, we investigated the anti-apoptotic effect of BV on tumor necrosis factor (TNF)-alpha with actinomycin (Act) D induces apoptosis in hepatocytes. TNF-alpha/Act D-treated hepatocytes were exposed to different low concentration (1, 10 and 100 ng/mL) of BV. Our results showed statistically significant inhibition in DNA damage caused by BV treatment compared to corresponding TNF-alpha/Act D-treated hepatocytes. BV suppressed TNF-alpha/Act Dtreated activation of bcl-2 family and caspase family, which resulted in inhibition of cytochrome c release and PARP cleavage. These results demonstrate that low concentration BV possess a potent suppressive effect on anti-apoptotic responses of TNF-alpha/Act D-treated hepatocytes and suggest that these compounds may contribute substantial therapeutic potential for the treatment of liver diseases.

Study Type : In Vitro Study

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