Effects of Photobiomodulation on Functionality in Wistar Rats with Sciatic Nerve Injury.
Photochem Photobiol. 2018 Nov 9. Epub 2018 Nov 9. PMID: 30411797
A peripheral nerve injury (PNI) can result in motor or sensory disorders. Low-level laser therapy (LLLT) has demonstrated positive results as a treatment option for PNI. Wistar rats were divided into five groups: Control, Injury, Injury+LLLTn (nerve), Injury+LLLTm (muscle) and Injury+LLLTn+m (nerve and muscle irradiation). The groups were analyzed after one, two, three and four weeks. PNI was achieved by crushing the sciatic nerve. Laser treatment (780nm, 3.2J) was realized over the nerve and/or tibialis anterior muscle. In gait analyses, the groups irradiated over the nerve demonstrated an improvement after two weeks. In the analysis of mechanical sensitivity, the Injury+LLLTn demonstrated a reduction after one week in comparison to Injury group; the Injury+LLLTn+m and Injury+LLLTm demonstrated an increase after two weeks in comparison to Injury group; and the irradiated groups demonstrated a reduction in nociception after four weeks in comparison to Injury group. In the analysis of muscle atrophy, the Injury+LLLTn demonstrated more muscle mass after two weeks. LLLT improve functional aspects related to gait, mechanical sensitivity and muscle mass, with better results regarding motor aspects and muscle mass when administered over the injured nerve and better results regarding sensory aspects when administered over the muscle. This article is protected by copyright. All rights reserved.