Article Publish Status: FREE
Abstract Title:

Beneficial Cardiovascular Effects of Hydroalcoholic Extract from Crocus Sativus in Hypertension Induced by Angiotensin II.

Abstract Source:

J Pharmacopuncture. 2019 Jun ;22(2):95-101. Epub 2019 Jun 30. PMID: 31338249

Abstract Author(s):

Abdolali Faramarzi Plangar, Akbar Anaeigoudari, Abolfazl KhajaviRad, Mohammad Naser Shafei

Article Affiliation:

Abdolali Faramarzi Plangar


Objectives: Angiotensin II (AngII), a major product of renin-angiotensin system (RAS) has important role in induction of hypertension and antihypertensive effect of several medicinal plant was mediated by effect on this agent. Therefore, this study examined the possible effect of hydroalcoholic extract ofon hypertension induced by AngII.

Methods: Six groups (n = 6) of rats were used as follow: 1) Control, 2) AngII (300 ng/kg), 3) Losartan (Los, 10 mg/kg) + AngII and 4-6)extract (10, 20&40 mg/kg,) + AngII. The femoral artery and vein were cannulated for recording cardiovascular parameters and drugs administration, respectively. All drugs were injected intravenously (i.v). Los and all doses ofinjected 10 min before AngII. Systolic blood pressure (SBP), mean arterial blood pressure (MAP) and heart rate (HR) were recorded throughout the experiment and those peak changes (Δ) were calculated and compared to control and AngII.

Results: AngII significantly increasedΔMAP, ΔSBP and ΔHR than control (P<0. 01 to P<0.001) and these increments were significantly attenuated by Los. All doses ofsignificantly reduced peakΔMAP, ΔSBP, and ΔHR than AngII group (P<0. 05 to P<0.001). In addition, peakΔMAP, ΔSBP in doses 10 and 20 were significant than Los + AngII group (P<0.05 to P<0.01) but in dose 40 only MAP was significant (P<0.05). PeakΔHR in all doses of C sativus was not significant than Los+ AngII.

Conclusion: Regarding the improving effect of theextract on AngII induced hypertension, it seems that this ameliorating effect partly mediated through inhibition of RAS.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.