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Article Publish Status: FREE
Abstract Title:

The beneficial effects ofleaf on reproductive performance in mice.

Abstract Source:

Food Sci Nutr. 2019 Feb ;7(2):738-746. Epub 2019 Jan 22. PMID: 30847152

Abstract Author(s):

Bin Zeng, Junyi Luo, Peng Wang, Lin Yang, Ting Chen, Jiajie Sun, Meiying Xie, Meng Li, Haojie Zhang, Jiajian He, Yongliang Zhang, Qianyun Xi

Article Affiliation:

Bin Zeng

Abstract:

is a tropical plant with high nutritional and medicinal value. Recent studies have reported its remarkable effects in inflammatory, antioxidative, and anti-diabetes modulations, but there was no significant report on its role in animal breeding. In this study, we investigated the effects of dietaryleaf (MOL) on reproductive performances in mice. We studied the reproductive performance of mice for six consecutive gestations. Mice fed with 4% MOL diet showed improved litter size, litter birth weight, and litter survivals until weaning age compared to control mice fed with normal diet (<0.05). Mice fed with MOL diet did not change weight and organ coefficients. Serum malondialdehyde (MDA) concentrations in both male and female mice were significantly decreased by dietary MOL (<0.05), but glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD) were unchanged. For male, dietary MOL significantly reduced sperm abnormality rate (<0.05) and Bcl2-associated X protein (Bax) expression in testis (<0.05), but did not affect serum testosterone and the expression levels of androgen receptor (AR), phosphoglycerate kinase 2 (Pgk2), protamine2 (Prm2), and B cell leukemia/lymphoma 2 (Bcl2) in testis. For female, dietary MOL did not change serum estradiol and the expressions of estrogen receptor beta (ERβ), Bcl2, Bax, and vascular endothelial growth factor receptor (VEGFR) in ovary. In summary, MOL increased litter size and antioxidant ability, reduced the rate of sperm abnormality and the expression of Bax. Therefore, MOL may serve as a functional feed addictive for improving animal reproductiveperformance.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Fertility Agents : CK(2) : AC(1)

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