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Abstract Title:

Benefit of passion fruit as an anti-ulcerogenic diet: Scientific evidence by in-vitro and in-silico H+/K+ATPase inhibitory activity assessment.

Abstract Source:

Curr Comput Aided Drug Des. 2019 Oct 25. Epub 2019 Oct 25. PMID: 31654519

Abstract Author(s):

Vineeth Ajaya Kumar, Mridula Ramkumar, S K Kanthlal

Article Affiliation:

Vineeth Ajaya Kumar

Abstract:

BACKGROUND: H+/K+ ATPase a well-known protein present in the parietal cells is a better target for the prevention and treatment of the disease. Flavonoids have been reported to elicit beneficial effect by inhibiting the proton pump as well as by antioxidant mechanism.

METHODOLOGY: In this study chloroform fraction of hydro-alcoholic extract of passion fruit was screened for proton pump inhibitory assay using goat parietal cell. Report and conclusion: The flavonoid rich fruit possess a good radical scavenging activity against DPPH. 10.41µg/mL is sufficient to inhibit the 50% activity of the ATPase enzyme of goat parietal cell. A synergistic activity was also achieved by the fruit with sub-effective doses of lansoprazole. Fenton's oxidation was also protected by the fruit induced by H2O2. Including the in-silico findings, the beneficial potency of passion fruit in curing ulcer has been evidenced and perhaps the fruit can be a good dietary supplement for the prevention and its associated complications.

Study Type : In Vitro Study

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Sayer Ji
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