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Abstract Title:

Benzylisoquinoline alkaloids fromGaertn. petals with antiausterity activities against the HeLa human cervical cancer cell line.

Abstract Source:

Z Naturforsch C J Biosci. 2021 May 21. Epub 2021 May 21. PMID: 34019754

Abstract Author(s):

Juthamart Maneenet, Ashraf M Omar, Sijia Sun, Min Jo Kim, Supawadee Daodee, Orawon Monthakantirat, Chantana Boonyarat, Yaowared Chulikhit, Suresh Awale

Article Affiliation:

Juthamart Maneenet

Abstract:

Ethanolic extract ofpetals showed preferential cytotoxic activity against HeLa human cervical cancer cell line with a PCvalue of 10.4 μg/mL. This active extract was subjected to a phytochemical investigation study which led to the isolation of nine benzylisoquinoline alkaloids (-). The isolated compounds exhibited potent antiausterity activities. Moreover, under nutrient-deprived conditions, (-)-lirinidine () induced remarkable alterations in HeLa cell morphology including cell shrinkage and plasma blebbing leading to total cell death within 10 h. Mechanistically,was found to inhibit Akt/mTOR signaling pathway. It also induced apoptosis by promoting caspase-3 activation and inhibiting Bcl-2 expression. Therefore, benzylisoquinoline alkaloids skeleton can be considered as a promising scaffold for the anticancer drug development against cervical cancer.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Apoptotic : CK(6986) : AC(6931)

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