Benzylisoquinoline alkaloids from Nelumbo nucifera Gaertn. petals with antiausterity activities against the HeLa human cervical cancer cell line. - GreenMedInfo Summary
Benzylisoquinoline alkaloids fromGaertn. petals with antiausterity activities against the HeLa human cervical cancer cell line.
Z Naturforsch C J Biosci. 2021 May 21. Epub 2021 May 21. PMID: 34019754
Juthamart Maneenet
Ethanolic extract ofpetals showed preferential cytotoxic activity against HeLa human cervical cancer cell line with a PCvalue of 10.4 μg/mL. This active extract was subjected to a phytochemical investigation study which led to the isolation of nine benzylisoquinoline alkaloids (-). The isolated compounds exhibited potent antiausterity activities. Moreover, under nutrient-deprived conditions, (-)-lirinidine () induced remarkable alterations in HeLa cell morphology including cell shrinkage and plasma blebbing leading to total cell death within 10 h. Mechanistically,was found to inhibit Akt/mTOR signaling pathway. It also induced apoptosis by promoting caspase-3 activation and inhibiting Bcl-2 expression. Therefore, benzylisoquinoline alkaloids skeleton can be considered as a promising scaffold for the anticancer drug development against cervical cancer.