Berbamine showed dose-dependent cell growth inhibition effects against A549 cells. - GreenMedInfo Summary
In vitro and in vivo antitumor evaluation of berbamine for lung cancer treatment.
Asian Pac J Cancer Prev. 2014 ;15(4):1767-9. PMID: 24641406
PURPOSE: Lung cancer, one of the most frequently diagnosed cancers in the world, is characterized by relatively high morbidity and mortality. Berbamine (BER) has been initially reported to exert anti-proliferative effects against a series of cancers.
METHODS: In this study the in vitro cytotoxicity of BER was measured by MTT assay. In vivo anti-cancer efficacy of BER was assessed in A549 xenografts.
RESULTS: Cytotoxicity tests showed dose-dependent cell growth inhibition effects of BER against A549 cells. Moreover, BER significantly reduced the growth of lung cancer in a dose-dependent manner in nude mice with prolonged survival time.
CONCLUSION: Therefore, BER might be in herbal medicine for cancer therapy and further efforts are needed to explore therapeutic strategies.