Berberine attenuates olanzapine induced-metabolic syndrome. - GreenMedInfo Summary
Berberine attenuates olanzapine induced-metabolic syndrome.
J Pak Med Assoc. 2019 Aug ;69(Suppl 3)(8):S88-S92. PMID: 31603885
Marwa Salih Al-Naimi
Objective: To elucidate the protective effect of berberine on olanzapine induced-metabolic syndrome.
Methods: This prospective experimental study involved thirty Sprague-Dawley male rats which were divided into three groups. Group A (n=10): Rats treated with distilled water, Group B (n=10): Rats treated with olanzapine, Group C (n=10): Rats treated with olanzapine plus berberine. The duration of the study was 8 weeks, baseline and follow up data were evaluated. Fasting blood glucose(FBG) total cholesterol (TC), triglyceride (TG) and high-density lipoprotein (HDL), Low density lipoprotein (LDL), atherogenic index of plasma (AI), fasting serum insulin level, insulin resistance,β- cell function and insulin sensitivity were evaluated.SPSS 20.
Results: Olanzepine led to significant deterioration in gluco-metabolic profile compared with control P<0.01. Olanzapine plus berberine improved body weight, FBG, FSI, HOMA-IR and QUICKI compared with olanzapine P=0.0001.
Conclusions: Berberine attenuates olanzapine induced-metabolic via amelioration of gluco-lipid disturbances.