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Abstract Title:

Effect of Berberine on Angiogenesis and HIF-1α / VEGF Signal Transduction Pathway in Rats with Cerebral Ischemia - Reperfusion Injury.

Abstract Source:

J Coll Physicians Surg Pak. 2018 Oct ;28(10):753-757. PMID: 30266118

Abstract Author(s):

Hailin Liu, Xiangyang Ren, Congmin Ma

Article Affiliation:

Hailin Liu

Abstract:

OBJECTIVE: To investigate the effect of berberine on angiogenesis and signal transduction pathway of hypoxia-inducible growth factor-1α (HIF-1α) / vascular endothelial growth factor (VEGF) in rats with cerebral ischemia-reperfusion injury.

STUDY DESIGN: An experimental study.

PLACE AND DURATION OF STUDY: Luoyang Central Hospital Affiliated with Zhengzhou University, China, from 2016 to 2017.

METHODOLOGY: Forty-five rats were randomly divided into control group, model group and berberine group, 15 rats in each group. The model of rat with cerebral ischemia-reperfusion injury was duplicated by suture method. Neurological score was evaluated before, after operation, and 7 days after administration. Microvessel density (MVD) of cerebral ischemia- reperfusion cortex was detected by immunohistochemistry. HIF-1α mRNA and VEGF mRNA of cerebral ischemia- reperfusion cortex were detected by RT-PCR. HIF-1α, and VEGF protein expression of cerebral ischemia-reperfusion cortex was detected by Western Blotting.

RESULTS: After operation and 7 days of administration, the neurological scores of the control group, model group, and berberine group were different (all p<0.001). After 7 days of administration, neurological score of berberine group was lower than that of model group (p<0.001), MVD, HIF-1α mRNA and VEGF mRNA expression. HIF-1α and VEGF protein expression levels were lower in model group than berberine group (all p<0.001).

CONCLUSION: Berberine can promote angiogenesis in the rat with cerebral ischemia-reperfusion injury. Its mechanism may be activation of HIF-1α / VEGF signal transduction pathway.

Study Type : Animal Study

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