n/a
Article Publish Status: FREE
Abstract Title:

Berberine enhances L1 expression and axonal remyelination in rats after brachial plexus root avulsion.

Abstract Source:

Brain Behav. 2020 Aug 7:e01792. Epub 2020 Aug 7. PMID: 32770668

Abstract Author(s):

Shuangxi Chen, Bing He, Guijuan Zhou, Yan Xu, Lin Wu, Yangzhi Xie, Yihui Li, Shuangqin Chen, Jianghua Huang, Heng Wu, Zijian Xiao

Article Affiliation:

Shuangxi Chen

Abstract:

BACKGROUND AND PURPOSE: Enhanced remyelination of the regenerated axons results in functional re-innervation and improved functional motor recovery after brachial plexus root avulsion (BPRA). The neural cell adhesion molecule L1 (L1CAM, L1) regulates myelination and promotes regeneration after acute injury in the nervous system. Berberine (BBR) can exert neuroprotective roles against the lesion. Herein, we investigated whether berberine (BBR) can affect the expression of L1 and enhance the axonal remyelination in rats following BPRA.

METHODS: The surgical procedures were performed to build the rat brachial plexus avulsion and re-implantation model, and then, the rats were treated with BBR. After the rehabilitation for 12 weeks, the musculocutaneous nerves were collected for quantitative real-time PCR, Western blot analysis, and histochemical and immunofluorescence staining.

RESULTS: We observed that, BBR treatment ameliorated the abnormal musculocutaneous nerve fibers morphology, up-regulated the L1 expression, increased the myelination-related genes, decreased the differentiated-associated genes, and up-regulated the phosphorylation of ERK.

CONCLUSION: These results suggest that BBR may enhance L1 expression and promote axonal remyelination after spinal root avulsion.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Regenerative : CK(52) : AC(28)

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.