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Abstract Title:

[Effects and mechanism of berberine on the hypertensive renal injury rats induced by enriched high fat-salt-fructose diet].

Abstract Source:

Zhong Yao Cai. 2011 Mar ;34(3):412-5. PMID: 21823461

Abstract Author(s):

Hong-Bin Li, Ying Cai, Chun-Li Qi, Jun-Hua Lv

Article Affiliation:

The First Affiliated Hospital, Guangzhou 510632, China.

Abstract:

OBJECTIVE: To study the effects of berberine on hypertensive renal injury model in rats fed by enriched high fat-salt-fructose diet .

METHODS: hypertensive renal injury model was esteblished by feeding enriched high fat-salt-fructose diet for 8 weeks. On the basis of animal blood pressure, hypertensive rats were randomly divided into model group (10 rats, distilled water), captopril group (10 rats,25 mg/kg), berberine high dose group (10 rats, 300 mg/kg) and low dose group (10 rats, 100 mg/kg). These rats were fed by enriched high fat-salt-fructose diet and treated by intragastric administration with drugs for 4 weeks. And normal control group (10 rats) was set Blood pressure was determined at 0, 4, 8, 10, 12 weekend,and after 4 weeks of drugs treatment, getting urine to determine urine protein, taking blood serum to determine blood urea nitrogen, serum creatinine,GHb,MDA and activity of SOD. The content of H2O2 and GSH-Px and activity of CAT in kidney tissues were determined also.

RESULTS: Compared with normal control group, blood pressure, urine protein, blood urea nitrogen, serum creatinine and MDA and GHb in serum of model rats obviously increased (P<0.01), the activity of SOD decreased (P<0.01), higher content of H2O2 and lower content of GSH-Px and activity of CAT (P<0.01) in the kidney tissues. Treated with berberine for 4 weeks, elevated blood pressure and heightened levels of urine protein, blood urea nitrogen and serum creatinine in model rats were depressed significantly (P<0.01), and elevated the activity of SOD, lowed the levels of MDA and GHb in blood serum (P<0.01). At the same time, berberine increased the activities of GSH-Px and CAT (P<0.01) and slightly lowed the content of H2O2 in the kidney tissues.

CONCLUSION: Berberine has protecting effects on the hypertensive renal impairment model rats fed by enriched high fat-salt-fructose diet, which are concerned with elevated antioxidant capability in body and kidney tissues.

Study Type : Animal Study

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