Article Publish Status: FREE
Abstract Title:

Protection of Gastrointestinal Mucosa from Acute Heavy Alcohol Consumption: The Effect of Berberine and Its Correlation with TLR2, 4/IL1β-TNFα Signaling.

Abstract Source:

PLoS One. 2015 ;10(7):e0134044. Epub 2015 Jul 30. PMID: 26226164

Abstract Author(s):

Xin-Pei Wang, Fan Lei, Feng Du, Yu-Shuang Chai, Jing-Fei Jiang, Yu-Gang Wang, Xuan Yu, Xiao-Jin Yan, Dong-Ming Xing, Li-Jun Du

Article Affiliation:

Xin-Pei Wang


The purpose of the present study is to confirm the protective effect of berberine (BBR) on gastrointestinal injury caused by acute heavy alcohol exposure, an effect that has not been reported previously. Our research details how BBR protects against gastrointestinal injuries from acute alcohol exposure using both in vivo and in vitro experiments. Acute high alcohol concentrations lead to obvious damage to the gastrointestinal mucosa, resulting in necrosis of the intestinal mucosa. Oral administration of BBR was able to significantly reduce this alcohol-induced damage, inhibit increases of alcohol-induced TNFα and IL-1β expression in gastrointestinal mucosa as well as their upstream signals TLR2 and TLR4, and regulate cytokines that modulate tight junctions. Alcohol consumption is a popular human social behavior worldwide, and the present study reports a comprehensive mechanism by which BBR protects against gastrointestinal injuries from alcohol stress, providing people with a novel application of BBR.

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