Abstract Title:

Berberine protects against ischemia-reperfusion injury: a review of evidence from animal models and clinical studies.

Abstract Source:

Pharmacol Res. 2019 Aug 7:104385. Epub 2019 Aug 7. PMID: 31400402

Abstract Author(s):

Dai-Qiang Liu, Shu-Ping Chen, Jia Sun, Xiao-Mei Wang, Nan Chen, Ya-Qun Zhou, Yu-Ke Tian, Da-Wei Ye

Article Affiliation:

Dai-Qiang Liu


Ischemia-reperfusion (I/R) injury is accompanied with high morbidity and mortality and has seriously negative social and economic influences. Unfortunately, few effective therapeutic strategies are available to improve its outcome. Berberine is a natural medicine possessing multiple beneficial biological activities. Emerging evidence indicates that berberine has potential protective effects against I/R injury in brain, heart, kidney, liver, intestine and testis. However, up-to-date review focusing on the beneficial role of berberine against I/R injury is not yet available. In this paper, results from animal models and clinical studies are concisely presented and its mechanisms are discussed. We found that berberine ameliorates I/R injury in animal models via its anti-oxidant, anti-apoptotic and anti-inflammatory effects. Moreover, berberine also attenuates I/R injury by suppressing endoplasmic reticulum stress and promoting autophagy. Additionally, regulation of periphery immune system may also contributes to the beneficial effect of berberine against I/R injury. Although clinical evidence is limited, the current studies indicate that berberine may attenuate I/R injury via inhibiting excessive inflammatory response in patients. Collectively, berberine might be used as an alternative therapeutic strategy for the management of I/R injury.

Study Type : Review

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