Article Publish Status: FREE
Abstract Title:

Berberine in the treatment of ulcerative colitis: A possible pathway through Tuft cells.

Abstract Source:

Biomed Pharmacother. 2020 Dec 24 ;134:111129. Epub 2020 Dec 24. PMID: 33348308

Abstract Author(s):

Xinyu Xiong, Zhe Cheng, Fan Wu, Meilin Hu, Zhimin Liu, Ruolan Dong, Guang Chen

Article Affiliation:

Xinyu Xiong


Ulcerative colitis (UC) is an inflammatory bowel disease with complex pathogenesis, which is affected by genetic factors, intestinal immune status and intestinal microbial homeostasis. Intestinal epithelial barrier defect is crucial to the development of UC. Berberine, extracted from Chinese medicine, can identify bitter taste receptor on intestinal Tuft cells and activate IL-25-ILC2-IL-13 immune pathway to impair damaged intestinal tract by promoting differentiation of intestinal stem cells, which might be a potential approach for the treatment of UC.

Study Type : In Vitro Study

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