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Article Publish Status: FREE
Abstract Title:

Bergamot Essential Oil Attenuates Anxiety-Like Behaviour in Rats.

Abstract Source:

Molecules. 2017 Apr 11 ;22(4). Epub 2017 Apr 11. PMID: 28398260

Abstract Author(s):

Laura Rombolà, Laura Tridico, Damiana Scuteri, Tsukasa Sakurada, Shinobu Sakurada, Hirokazu Mizoguchi, Pinarosa Avato, Maria Tiziana Corasaniti, Giacinto Bagetta, Luigi Antonio Morrone

Article Affiliation:

Laura Rombolà

Abstract:

Preclinical studies have recently highlighted that bergamot essential oil (BEO) is endowed with remarkable neurobiolological effects. BEO can affect synaptic transmission, modulate electroencephalographic activity and it showed neuroprotective and analgesic properties. The phytocomplex, along with other essential oils, is also widely used in aromatherapy to minimize symptoms of stress-induced anxiety and mild mood disorders. However, only limited preclinical evidences are actually available. This study examined the anxiolytic/sedative-like effects of BEO using an open field task (OFT), an elevated plus-maze task (EPM), and a forced swimming task (FST) in rats. This study further compared behavioural effects of BEO to those of the benzodiazepine diazepam. Analysis of data suggests that BEO induces anxiolytic-like/relaxant effects in animal behavioural tasks not superimposable to those of the DZP. The present observations provide further insight to the pharmacological profile of BEO and support its rational use in aromatherapy.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Anti-Anxiety Agents : CK(356) : AC(59)
Additional Keywords : Essential Oils : CK(181) : AC(69)

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