Cancer chemoprevention by citrus pulp and juices containing high amounts ofβ-cryptoxanthin and hesperidin.
J Biomed Biotechnol. 2012 ;2012:516981. Epub 2011 Nov 24. PMID: 22174562
The Tohkai Institute of Cytopathology: Cancer Research and Prevention, 5-1-2 Minami-uzura, Gifu City, Gifu 500-8285, Japan. email@example.com
β-Cryptoxanthin, a carotenoid, and hesperidin, a flavonoid, possess inhibitory effects on carcinogenesis in several tissues. We recently have prepared a pulp (CHRP) and citrus juices (MJ2 and MJ5) from a satsuma mandarin (Citrus unshiu Mar.) juice (MJ). They contain high amounts of β-cryptoxanthinand hesperidin. We have demonstrated that CHRP and/or MJs inhibit chemically induced rat colon, rat tongue, and mouse lung tumorigenesis. Gavage with CHRP resulted in an increase of activities of detoxifying enzymes in the liver, colon, and tongue rats'. CHRP and MJs were also able to suppress theexpression of proinflammatory cytokines and inflammatory enzymes in the target tissues. This paper describes the findings of our in vivo preclinical experiments to develop a strategy for cancer chemoprevention of colon, tongue, and lung neoplasms by use of CHRP and MJs.