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Abstract Title:

Betanin reduces organophosphate induced cytotoxicity in primary hepatocyte via an anti-oxidative and mitochondrial dependent pathway.

Abstract Source:

Pestic Biochem Physiol. 2018 Jan ;144:71-78. Epub 2017 Dec 2. PMID: 29463411

Abstract Author(s):

Elham Ahmadian, Ahmad Yari Khosroushahi, Mohammad Ali Eghbal, Aziz Eftekhari

Article Affiliation:

Elham Ahmadian

Abstract:

Organophosphates (OP) are potent pesticide commonly utilized in agricultural and domestic use. However, plentitude of data represent their side effects in different body tissues. We attempted to study whether betanin (a natural pigment) is able to mitigate some OPs-induced hepatotoxicity in primary rat hepatocytes. Cell viability, lactate dehydrogenase (LDH) leakage, reactive oxygen species (ROS) formation, lipid peroxidation (LPO), glutathione (GSH) depletion and mitochondrial depolarization were tested as toxicity markers. The outcomes revealed that betanin (25μM) significantly increased cell viability, plummeted ROS formation and LPO, restored cellular GSH reservoirs and protected mitochondria after chlorpyrifos (CPF) (300μM), diazinon (DZN) (600μM) and dichlrovos (DDVP) (400μM) treatment. Taken together, all data suggests the potential protective role of betanin in OPs-induced hepatotoxicity in which the mechanism appears to be inhibition of ROS formation and mitochondrial protection.

Study Type : In Vitro Study
Additional Links
Substances : Betanin
Pharmacological Actions : Antioxidants : CK(14410) : AC(5758)

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