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Article Publish Status: FREE
Abstract Title:

Actions ofagainst Hyperuricemia through XOD and Bioactives Screened by Molecular Modeling.

Abstract Source:

Int J Mol Sci. 2018 Oct 18 ;19(10). Epub 2018 Oct 18. PMID: 30340390

Abstract Author(s):

Tianqiao Yong, Shaodan Chen, Danling Liang, Dan Zuo, Xue Diao, Chenling Deng, Yuning Wu, Huiping Hu, Yizhen Xie, Diling Chen

Article Affiliation:

Tianqiao Yong

Abstract:

is an edible mushroom and also a remedy against various diseases, especially metabolic syndrome. In this paper we report the actions of an ethanol extract of(IOE) against hyperuricemia in hyperuricemic mice, and the screen of bioactives. The extract (IOE) was prepared by extractingat 65°C with ethanol, and characterized by HPLC. IOE at low, middle, and high doses reduced serum uric acid (SUA) of hyperuricemic mice (353 μmol/L) to 215, 174, and 152 μmol/L (<0.01), respectively, showing similar hypouricemic effectiveness to the positive controls. IOE showed a non-toxic impact on kidney and liver functions. Of note, IOE suppressed xanthine oxidase (XOD) activity in serum and liver, and also down-regulated renal uric acid transporter 1 (URAT1). Four compounds hit highly against XOD in molecular docking. Overall, the four compounds all occupied the active tunnel, which may inhibit the substrate from entering. The ICof betulin was assayed at 121.10± 4.57 μM, which was near to that of allopurinol (148.10 ± 5.27 μM). Betulin may be one of the anti-hyperuricemia bioactives in.

Study Type : Animal Study

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