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Abstract Title:

Betulinic Acid Kills Colon Cancer Stem Cells.

Abstract Source:

Curr Stem Cell Res Ther. 2015 Dec 3. Epub 2015 Dec 3. PMID: 26647913

Abstract Author(s):

Lisette Potze, Simone di Franco, Jan H Kessler, Giorgio Stassi, Jan Paul Medema

Article Affiliation:

Lisette Potze

Abstract:

Cancer stem cells (CSCs) are considered to be the origin of cancer and it is suggested that they are resistant to chemotherapy. Current therapies fail to eradicate CSCs and therefore select a resistant cell subset that is able to facilitate tumor recurrences. Betulinic acid (BetA) is a broad acting natural compound, shown to induce cell death via the inhibition of the stearoyl-CoA- desaturase (SCD-1). This enzyme converts saturated fatty acids into unsaturated fatty acids and is over-expressed in tumor cells. Here we show that BetA induces rapid cell death in all colon CSCs tested and is able to affect the CSCs directly as shown, via the loss of clonogenic capacity. Similar results were observed with inhibition of SCD-1, suggesting that SCD-1 activity is indeed a vulnerable link in colon CSCs and can be considered an ideal target for therapy in colon cancer.

Study Type : In Vitro Study

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Sayer Ji
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