Kiwifruit ofcv. Bidan has in vitro antioxidative, anti-inflammatory and immunomodulatory effects on macrophages and splenocytes isolated from male BALB/c mice.
Food Sci Biotechnol. 2018 Oct ;27(5):1503-1511. Epub 2018 Jan 24. PMID: 30319861
Kiwifruit is known to contain considerable amount of antioxidative phenolics. The objective of this study was to evaluate the antioxidative, anti-inflammatory and immunomodulatory effects ofcv. Bidan andcv. Hayward kiwifruits. The antioxidant capacity of kiwifruit was measured with the DPPH, ABTS and ORAC assays, and was significantly ( < 0.05) higher in cv. Bidan than in cv. Hayward. The production of proinflammatory cytokines interleukin-6, interleukin-12 and tumor necrosis factor-α by peritoneal macrophages from male BALB/c mice was significantly ( < 0.05) lower following treatment of cv. Bidan extracts than after treatment with lipopolysaccharide alone. Cv. Bidan extracts significantly ( < 0.05) increased the proliferation of splenocytes stimulated with an anti-CD3 antibody and significantly ( < 0.05) reduced their interferon-γ secretion. Taken together, these findings suggest that cv. Bidan kiwifruit is rich in antioxidants and may be a source of anti-inflammatory and immunomodulatory agents.