alleviates irritable bowel syndrome-related visceral hypersensitivity and microbiota dysbiosis via Paneth cell regulation.
Gut Microbes. 2020 11 9 ;12(1):1782156. Epub 2020 Jun 25. PMID: 32584650
Although the oral administration of() relieves the signs of irritable bowel syndrome (IBS) in clinical settings, the mechanisms underlying its effects are unclear. In this study, we evaluated the precise effects ofon IBS via regulation of Paneth cell function. We confirmed the beneficial effects ofon defecation habits and visceral hypersensitivity in WAS rats. Further analysis revealed thatenhanced mucosal repair, promoted lysozyme production, and ameliorated dysbiosis of the microbiota in WAS rats. These processes are closely correlated with Paneth cell functions., we incubated primary cultured enteroids withand found thatpromoted the proliferation of these organoids; this may be attributed to the upregulation of the stem niche factors WNT3A and TGF-β, which are secreted by Paneth cells. Based on our findings, we propose thatrelieves IBS by restoring the antimicrobial activity and stem niche maintenance function of Paneth cells.