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Abstract Title:

-fermented rice bran and rice bran supplementation affects the gut microbiome and metabolome.

Abstract Source:

Benef Microbes. 2019 Dec 9 ;10(8):823-839. Epub 2019 Sep 29. PMID: 31965839

Abstract Author(s):

N J Nealon, K D Parker, P Lahaie, H Ibrahim, A K Maurya, K Raina, E P Ryan

Article Affiliation:

N J Nealon

Abstract:

This study investigated gut microbiota composition along with food, host, and microbial derived metabolites in the colon and systemic circulation of healthy mice following dietary rice bran and fermented rice bran intake. Adult male BALB/c mice were fed a control diet or one of two experimental diets containing 10% w/w rice bran fermented byor 10% w/w non-fermented rice bran for 15 weeks. Metabolomics was performed on the study diets (food), the murine colon and whole blood. These were analysed in concert with 16S rRNA amplicon sequencing of faeces, caecum, and colon microbiomes. Principal components analysis of murine microbiota composition displayed marked separation between control and experimental diets, and between faecal and tissue (caecum and colon) microbiomes. Colon and caecal microbiomes in both experimental diet groups showed enrichment of, andrelated amplicon sequence variants compared to control. Bacterial composition was largely similar between experimental diets. Metabolite profiling revealed 530 small molecules comprising of 39% amino acids and 21% lipids that had differential abundances across food, colon, and blood matrices, and statistically significant between the control, rice bran, and fermented rice bran groups. The amino acid metabolite, N-delta-acetylornithine, was notably increased byrice bran fermentation when compared to non-fermented rice bran in food, colon, and blood. These findings support that dietary intake of rice bran fermented withmodulates multiple metabolic pathways important to the gut and overall health.

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